摘要: The introduction of new assays for point mutations in chromosomal DNA has enabled us to identify activated ras genes a large number human tumors (Table I; ref.1). Thus it became clear that certain tumor types never or only occasionally harbor mutated gene, whereas other have an gene more less frequently (20% 90% the cases). On basis clinical histopathological features, does not differ from same type not. This indicates activation is essential event. However, since proteins cell-transforming properties, and (nearly) all malignant cells carry likely contribute development tumors. Apparently, genetic events similar effects as activation.
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