Review: Immune cells and mediators of inflammatory arthritis.
作者： Georg Schett
DOI: 10.1080/08916930701694717
关键词:
摘要: Cytokine expression in the inflamed synovial membrane of patients with rheumatoid arthritis and other forms chronic inflammatory leads to formation osteoclasts. These cells are primarily involved resorption mineralized cartilage bone thus participate joint damage course arthritides. Osteoclastogenesis is driven by cytokines such as RANKL, MCSF but also classical proinflammatory mediators TNF, IL-1 IL-6. Inhibition osteoclast has proven an effective approach inhibit structural experimental preliminary data suggest that approaches human RA.
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