Studies on the clinical pharmacology of prazosin. II: The influence of indomethacin and of propranolol on the action and disposition of prazosin.

摘要: 1 The possibility of pharmacodynamic and pharmacokinetic interactions prazosin with indomethacin propranolol have been studied in healthy subjects. 2 In four out nine individuals considerably attenuated prazosin-induced hypotension, but noradrenaline concentrations were unchanged from the day when blood pressure fell greatly. effect other five subjects was not influenced by indomethacin. 3 Indomethacin prevented rise plasma renin activity seen following administration alone. 4 Propranolol did prevent syncope associated first dose prazosin. 5 affected neither absorption nor elimination 6 It is concluded that certain can largely hypotensive parazosin, possible increasing adrenergic receptor sensitivity. theoretical could influence disposition or substantiated.