Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease
作者： Ran Reshef , Selina M. Luger , Elizabeth O. Hexner , Alison W. Loren , Noelle V. Frey
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摘要: Background Graft-versus-host disease (GVHD) is a major barrier to successful allogeneic hematopoietic stem-cell transplantation (HSCT). The chemokine receptor CCR5 appears play role in alloreactivity. We tested whether blockade would be safe and limit GVHD humans. Methods the vitro effect of antagonist maraviroc on lymphocyte function chemotaxis. then enrolled 38 high-risk patients single-group phase 1 2 study reduced-intensity HSCT that combined with standard prophylaxis. Results Maraviroc inhibited internalization chemotaxis without impairing T-cell or formation hematopoietic-cell colonies. In 35 who could evaluated, cumulative incidence rate (±SE) grade II IV acute was low at 14.7±6.2% day 100 23.6±7.4% 180. Acute liver gut were not observed before remained uncommon 180, resulting o...
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