Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis.
作者： Pierre Laurent–Puig , Patricia Legoix , Olivier Bluteau , Jacques Belghiti , Dominique Franco
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摘要: Background & Aims: To evaluate how characterization of genetic alterations can help in the elucidation of liver carcinogenesis pathways, 137 tumors were analyzed. Methods: High-density allelotype, p53, Axin1, and β-catenin gene mutations were determined. Alterations were analyzed according to clinical parameters. Results: Tumors could be divided into 2 groups according to chromosome stability status. In the first group, demonstrating a chromosome stability, β-catenin mutation associated with chromosome 8p losses were …
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