Erythropoietin update 2011

摘要: Traditionally, erythropoietin (EPO) is described as a hematopoietic cytokine, regulating proliferation and differentiation survival of the erythroid progenitors. The recent finding new sites EPO production wide spread distribution receptors (EPO-R) on endothelial cells, cardiomyocytes, renal cells well central peripheral nervous system raised possibility that may exert pleiotropic actions several targets. Indeed studies (mainly preclinical) have documented protective, non-hematopoietic, abilities in variety tissue. However, data obtained from clinical are more skeptical about these properties. This article provides comprehensive overview its derivatives.