Endoscopic ultrasound-guided fine-needle aspiration cytology of pancreatic neuroendocrine tumors: a study of 48 cases.

摘要: BACKGROUND. Neuroendocrine tumors (NETs) of the pancreas are relatively uncommon tumors. The objective this report was to describe cytopathologic and immunocytochemical features NETs obtained by endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA). METHODS. Forty-eight patients who were diagnosed with pancreatic based on EUS-guided FNA studied retrospectively (from 2002 2007). Clinical data, EUS findings, features, stains reviewed for study. final histopathologic diagnosis from each patient also available comparison. RESULTS. Forty-eight (28 men 20 women) ranged in age 16 years 86 selected had following clinical findings: solid or multiple masses computed tomography magnetic resonance imaging studies; simultaneous, suspicious, metastatic liver, mediastinum, and/or lung; hypoglycemia; endocrine neoplasia type 1 syndrome; von Hippel-Lindau primary NET small bowel. findings revealed head/uncinate, body/tail, simultaneously head/uncinate body/tail. Cytologically, 40 (histopathogically confirmed), 8 that suspicious (2 false-positive results, 6 histopathologically confirmed NETs). most helpful cytologic a richly cellular sample monotonous, poorly cohesive population medium-sized cells granular chromatin (salt pepper) plasmacytoid morphology. Immunocytochemistry neuroendocrine origin (material immunocytochemistry inadequate patients). CONCLUSIONS. The current results indicated is useful method NETs. Cytopathologic examination coordination can provide an accurate patients. Cancer (Cancer Cytopathol) 2008. © 2008 American Society.