Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye development.
作者： Yan Zhang , Jia You , Wenyan Ren , Xinhua Lin
DOI: 10.1016/J.YDBIO.2012.12.019
关键词:
摘要: The highly conserved janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is a well-known signaling system that involved in many biological processes. In Drosophila, this cascade activated by ligands the Unpaired (Upd) family. Therefore, regulation Upd distribution one key issues controlling JAK/STAT activity function. Heparan sulfate proteoglycans (HSPGs) are macromolecules regulate ligand proteins including Wingless, Hedgehog Decapentaplegic (Dpp). Here we show during Drosophila eye development, HSPGs also required normal activity. Loss HSPG biosynthesis enzyme Brother tout-velu (Botv), Sulfateless (Sfl), or glypicans Division abnormally delayed (Dally) Dally-like protein (Dlp) led to reduced levels extracellular reduction Overexpression dally resulted accumulation up-regulation Luciferase assay showed Dally promotes activity, dependent on its heparin chains. These data suggest Dlp essential for
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