Here, There, and Everywhere: The Ubiquitous Distribution of the Immunosignaling Molecule Lysophosphatidylcholine and Its Role on Chagas Disease.

摘要: Chagas disease is a severe illness, which can lead to death if the patients are not promptly treated. The caused by protozoan parasite Trypanosoma cruzi, mostly transmitted triatomine insect vector. There 8-10 million people infected with T. cruzi in world, but vector-borne transmission occurs only Americas, especially Latin America. About 30 % of chronically develop cardiac diseases and up 10 digestive, neurological or mixed disorders. Lysophosphatydilcholine (LPC) major phospholipid component oxidized low-density lipoproteins associated atherosclerosis-related tissue damage. Insect-derived LPC powerful chemoattractant for inflammatory cells at site bite, enhances invasion, inhibits production nitric oxide (NO) cruzi-stimulated macrophages. recognition ubiquitous presence on vector saliva, its itself both patient plasma as well role diverse host x interaction systems us compare distribution nature title famous Beatles song “Here, Everywhere” recorded exactly 50 years ago 1966. Here, we review findings pointing out such molecule an immunosignaling modulator transmission. Also, believe that future investigation connection this ubiquity immune may novel methods control transmission, infection pathogenesis.