The Influence of Folate and Multivitamin Use on the Familial Risk of Colon Cancer in Women

摘要: Low intake of folate and methionine heavy alcohol consumption have been associated with an increased overall risk colon cancer, possibly related to their role in methylation pathways. We estimated the relative (RR) cancer according a history colorectal first-degree categories folate, methionine, prospective cohort study 88,758 women who completed family detailed food frequency questionnaires. During 16 years follow-up, was diagnosed 535 women. The inverse association folic acid greater history. Compared consumed 200 microg or less acid/day, age-adjusted RR for those >400 microg/day 0.81 (95% confidence interval, 0.62-1.07) without 0.48 0.28-0.83) (P interaction = 0.02). influence markedly diminished by use multivitamins containing 0.04). High levels dietary also reduced effect 0.05), whereas moderate 0.004). Other factors did not significantly modify Our results suggest that higher regular avoidance may diminish excess disease.