Screening Strategies for Thyroid Disorders in the First and Second Trimester of Pregnancy in China

摘要: Background Thyroid dysfunction during pregnancy is associated with multiple adverse outcomes, but whether all women should be screened for thyroid disorders remains controversial. Objective To evaluate the effectiveness of targeted high risk case-finding approach identifying first and second trimesters pregnancy. Methods Levels stimulating hormone (TSH), free thyroxine (FT4), peroxidase antibodies (TPOAb) were measured in 3882 Chinese trimester pregnancy. All tested divided into or non-high groups, based on their history, findings from physical examination, other clinical features suggestive a disorder. Diagnosis was made according to standard trimester-specific reference intervals. The prevalence each group determined, feasibility screening focusing exclusively evaluated estimate ability finding dysfunction. Results The overt hypothyroidism hyperthyroidism higher than (0.8% vs 0, χ2 = 7.10, p 0.008; 1.6% 0.2%, 7.02, 0.008, respectively). hypothyroxinemia TPOAb positivity significantly (1.3% 0.5%, 4.49, 0.034; 11.6% 8.4%, 6.396, 0.011, total subclinical not statistically different between either trimester. Conclusion strategy failed detect majority pregnant disorders. Therefore, we recommend universal sTSH, FT4,