Structure-Activity Relationship of Chemical Penetration Enhancers

摘要: Transdermal drug delivery offers many advantages capable of improving patient health and quality life. However, the highly organized structure stratum corneum forms an effective barrier to permeation drugs. The use chemical penetration enhancers would significantly increase number candidates suitable for transdermal delivery. relationship between skin enhancement effect some extensively studied such as fatty acids, alcohols, terpenes, pyrrolidones, surfactants has been discussed in this chapter. A parabolic carbon chain length acids alcohols was observed with several Solid (saturated acids) had lower efficiency when compared liquid (unsaturated acids). Terpenes higher partition coefficient (LogP) values were found be more than those LogP. With carbonyl groups influenced enhancing activity effectively ring size. In general, ionic produced a greater flux drugs nonionic surfactants. Recent studies on structure-enhancement using different classes have increased our understanding subject, might facilitate development new dosage enhancers.