Antibody to S100a6 protein is a sensitive immunohistochemical marker for neurothekeoma.

摘要: Background: Neurothekeoma is a benign tumor of putative peripheral nerve sheath origin. It occurs in myxoid (classic) variant, cellular and intermediate (mixed) variant. Cellular neurothekeoma (CNT) usually involves the head neck or extremities young patients. Histologically, CNT can be confused with melanocytic fibrohistiocytic lesions. An immunohistochemical antibody panel often necessary to confirm histological impression exclude and/or lesions. Methods: Formalin-fixed, paraffin-embedded archival tissues were evaluated by immunohistochemistry using antibodies specific for S100A6 PGP9.5 11 cases (seven cellular, four myxoid). A variety other at time initial diagnosis. Results: All positive protein (four cases, weak/1+ ; seven strong/2+), corresponding 100% sensitivity. In contrast, eight (73% sensitivity) PGP9.5. negative S100B, as expected. Conclusions: Anti-S100A6 highly sensitive neurothekeomas, including CNT, and, our experience, superior sensitivity However, like used evaluating lacks specificity, has been demonstrated previous studies. Nevertheless, useful an evaluate lesions where differential diagnosis includes CNT.