The transcription levels and prognostic values of seven proteasome alpha subunits in human cancers.
作者： Yunhai Li , Jing Huang , Jiazheng Sun , Shili Xiang , Dejuan Yang
DOI: 10.18632/ONCOTARGET.13885
关键词:
摘要: // Yunhai Li 1, 2 , Jing Huang 1 Jiazheng Sun Shili Xiang Dejuan Yang Xuedong Ying Mengqi Lu Hongzhong Guosheng Ren Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital Medical University, Chongqing, China Department Endocrine Breast Surgery, Correspondence to: Li, email: tibetlhz@126.com Ren, rengs726@126.com Keywords: proteasome alpha subunits, cancer, oncomine, TCGA, Kaplan-Meier plotter Received: June 19, 2016 Accepted: December 01, Published: 10, 2016 ABSTRACT Proteasome subunits (PSMAs) have been shown to participate in the malignant progression human cancers. However, expression patterns prognostic values individual PSMAs remain elusive most In present study, we investigated mRNA levels seven different kinds cancers using Oncomine Cancer Genome Atlas (TCGA) databases. significance was also determined by Plotter PrognScan Combined with PSMA1-7 were significantly upregulated breast, lung, gastric, bladder head neck cancer compared normal tissues. Moreover, only PSMA6 PSMA5 not overexpressed colorectal kidney respectively. survival analyses based on Plotter, showed significant lung gastric cancer. Furthermore, potential correlations between outcomes observed ovarian melanoma PrognScan. These data indicated that might serve as novel biomarkers therapeutic targets for multiple further studies are needed explore detailed biological functions molecular mechanisms involved tumor progression.
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