Kinetics and Mechanisms of Action of Antibiotics on Microorganisms III.

摘要: The generation rate constants, k from N  =  0 e kt ,  > 0, for viable counts of Escherichia coli growth have been shown to be linearly dependent on the concentration, A antibiotics tetracycline and/or chloramphenicol, – . Alternative mechanisms action are by inhibition E. or kill superimposed an invariant rate. Methods and techniques developed obtain reproducible total Coulter counter statistically evaluated. For case where > 0, equivalent in presence studied, mode is inhibitory. dependence constants antibiotic concentration has independent inoculum size over a range 10 3 microorganisms/ ml. Studies media double half nutrients, metal-free, reduced, increased phosphate concentrations demonstrated no significant effects rates.