Regulatory T cells from active non-segmental vitiligo exhibit lower suppressive ability on CD8+CLA+ T cells.

摘要: Background: Recent studies have shown that vitiligo is a T-cell mediated autoimmune disease. Skin-homing cytotoxic T lymphocytes expressing cutaneous lymphocyte-associated antigen (CLA) been suggested to be responsible for the destruction of melanocytes in vitiligo. An aberration suppressive function regulatory cells (Tregs) has reported patients. However, whether weakened ability Tregs contributes hyper-activated skin homing CD8+CLA+ remains determined. Objectives: To investigate inhibition circulating on proliferation autologous non-segmental Methods: and were obtained from peripheral blood 13 patients 7 controls. The proliferative responses assessed absence or presence Tregs, levels Transforming Growth Factor β1(TGF-β1) IL-10 culture supernatants detected by enzyme-linked immunosorbent assay. Results: significantly higher active than stable control groups. exhibited lower inhibitory effect cells. TGF-β1 produced other groups anti-TGF-β1 antibodies could abrogate Tregs. Conclusions: functional activity compromised plays an important role mechanism