Distinction of differentiated type early gastric carcinoma with gastric type mucin expression

摘要: BACKGROUND Intestinal and diffuse gastric carcinomas differ in morphology growth behavior. Differentiated type carcinoma (DGC), which corresponds roughly with the intestinal of Lauren, can demonstrate phenotypic properties associated mucin expression brush border. However, their clinical significance is controversial. A classification based on phenotype border was performed to determine clinicopathologic diversity DGCs early stage. METHODS A total 120 specimens from 116 DGC patients definite submucosal invasion were evaluated both macroscopically histologically. All sections examined immunohistochemically human mucin, Muc-2, CD10 histochemically paradoxical concanavalin staining high iron Diamine-Alcian Blue. They classified into (G-type), (I-type), mixed (M-type), or null (N-type) phenotypes. The immunoreactivity E-cadherin β-catenin also investigated correlation between factors. RESULTS The G-type found be contrast I-type: an independent factor lymph node metastasis. Significant correlations observed complex that histologically: lymphatic invasion, metastasis, abnormal E-cadherin. significant difference proportion phenotypes papillary tubular observed. predominant carcinoma. CONCLUSIONS The adenocarcinoma should distinguished other types because increased malignant potential incipient phase reflected treatment stage DGCs, including endoscopic mucosal resection. Cancer 2000;89:724–32. © 2000 American Society.