作者: Lincoln Chin , Albert L. Picchioni , Bruce R. Duplisse
DOI: 10.1016/0041-008X(70)90085-2
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摘要: Abstract Time course blood- or liver-drug analyses were performed to investigate the action of activated charcoal on poisons in gastrointestinal tract. Blood was obtained from dogs treated orally with aspirin, pentobarbital, barbital, glutethimide, and liver rats chloroquine, chlorpheniramine, chlorpromazine. Test animals 1 min after drug administration. Control given only drugs. All concentration curves test markedly lower than those corresponding control animals. Semilogarithmic plots data suggest that dissociation charcoal-drug complexes, if it does occur, is inconsequential. Administration poisoning more effective reducing absorption drugs administration 30 poisoning. Repeated at 1- 12-hr intervals, an initial antidotal treatment, appears exert no additional inhibition poisons. Activated charcoal, a dose 5 times each poison, administered poisoning, effectively reduced mortality lethal doses chloroquine. Intoxication developed so rapidly some ineffective preventing death. This investigation confirms effectiveness treatment It also emphasizes need for immediate adequate absorbent management ingested