Age-associated increases in poor outcomes after traumatic brain injury: a report from the Japan Neurotrauma Data Bank.

摘要: Age is an important factor influencing outcome after severe traumatic brain injury (TBI). In general, the older victim, higher probability of a poor outcome. To investigate mechanism underlying link between age and outcome, data for 797 patients enrolled in Japan Neurotrauma Data Bank (JNTDB), aged 6 years or older, with Glasgow Coma Scale (GCS) scores 8 less on admission deterioration to that level within 48 h impact were analyzed. Thirty-eight percent ages 40 69 years, 24% than years. Older had rates mortality lower favorable The frequency mass lesions which associated poorer outcomes significantly increased age, but regardless intracranial lesion type, outcomes. GCS score occurrence systemic complications did not differ according age. Multiple was frequent patients. varied types likely caused by disparity young progression secondary injury. Alteration pathophysiological response, related development aging brain, probably contributes more irreversible damage patients, thus