Impact of comprehensive cardiovascular risk reduction programme on risk factor clustering associated with elevated blood pressure in an Indian industrial population.

摘要: Systolic blood pressure (SBP) exceeding 115 mmHg contributes to one-half of ischaemic heart disease (IHD) and cerebrovascular (CeVD) around the world1. The major contributors this global burden (BP) are emerging economies like India China as a consequence increased life-expectancy, urbanization, development affluence2. Several epidemiologic studies have demonstrated that systolic diastolic BP strong, continuous, graded positive association with cardiovascular (CVD) outcomes or life time risk CVD no indication critical value3–5. Nevertheless, clinical management strategies typically use thresholds for interventions reduce associated risk6. Hypertension appears cluster other metabolic factors dyslipidaemia, glucose intolerance, hyperinsulinaemia, obesity, hyperuricaemia more than would be expected by chance7,8. In Framingham study, hypertension in isolation was observed less 20 per cent time9. reasons clustering include insulin resistance sympathetic overactivity. Further, tendency these atherogenic traits elevated stepwise degree obesity9. Indian population is considered metabolically high group higher levels visceral adiposity, resistance, novel markers such C-reactive protein (CRP), adiponectin plasma leptin10,11. has not been studied before population. Demonstration important formulating reduction particularly individuals stage I prehypertension which widely prevalent severe stages hypertension. Here we report effect suboptimal large impact on factor clustering.