Association between DAZL polymorphisms and susceptibility to male infertility: systematic review with meta-analysis and trial sequential analysis
作者： Simin Zhang , Qiuqin Tang , Wei Wu , Beilei Yuan , Chuncheng Lu
DOI: 10.1038/SREP04642
关键词:
摘要: Several studies have investigated the association between polymorphisms in Deleted AZoospermia-Like (DAZL) gene and male infertility risk, but with inconsistent results. We aimed to derive a more precise estimation of relationship, therefore meta-analysis was performed. A total 13 case-control studies, including 2556 cases 1997 controls, were selected. Two DAZL investigated, namely T12A (Thr12 → Ala) T54A (Thr54 Ala). Our showed that > G is risk factor for (P = 0.047, OR 1.262, 95%CI 1.003–1.587). However, when using trial sequential analysis (TSA) confirm, we found effect turned out be false positive. In addition, significant polymorphism under co-dominant model (AG vs. AA: 4.364, 2.207–8.630, P < 0.001) dominant (OR 4.584, 2.320–9.058, 0.001). Stratified significantly strong present only Asians, not Caucasians. Further their biological functions are needed understand role these development infertility.
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