Identification of cytotoxic compound from Artocarpus communis leaves against P-388 cells.
作者： Puspa D.N. Lotulung , Sofa Fajriah , Muhammad Hanafi , Euis Filaila
DOI: 10.3923/PJBS.2008.2517.2520
关键词:
摘要: In the course of continuing research for finding bioactive compounds from Indonesian plants, leaves Artocarpus communis was extracted by ethanol. This extract partitioned with n-hexane-water (1:4) and then water dichloromethane. Dichloromethane purified column chromatography techniques on silica gel to afford yellow crystal (F-1). Based LC-MS, 1H-NMR 13C-NMR (1D 2D) spectra compared previous spectral data, it identified as prenylated flavonoid, 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl] 1-propanone. compound showed significant cytotoxicity against murine P-388 leukemia cells.
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