Geranyl dihydrochalcones from Artocarpus altilis and their antiausteric activity.
作者： Mai Thanh Thi Nguyen , Nhan Trung Nguyen , Khang Duy Huu Nguyen , Hien Thu Thi Dau , Hai Xuan Nguyen
关键词:
摘要: Human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cells low nutrient conditions is novel antiausterity strategy in anticancer drug discovery. In this study, methanolic extract leaves Artocarpus altilis showed 100 % preferential cytotoxicity against PANC-1 human nutrient-deprived at a concentration 50 µg/mL. Further investigation led isolation eight new geranylated dihydrochalcones named sakenins A–H (1–8) together with four known compounds (9–12). Among them, F (6) and H (8) were identified as potent cytotoxic candidates with PC50 values 8.0 µM 11.1 µM, respectively.
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