Microsatellite instability in colorectal cancer—the stable evidence

摘要: Microsatellite instability (MSI) is the molecular fingerprint of a deficient mismatch repair system. Approximately 15% colorectal cancers (CRC) display MSI owing either to epigenetic silencing MLH1 or germline mutation in one genes MLH1, MSH2, MSH6 PMS2. Methods detect are well established and routinely incorporated into clinical practice. A profile tumors has been described, leading concept an phenotype CRC. Studies have confirmed that better prognosis than microsatellite stable CRC, but do not necessarily same response chemotherapeutic strategies used treat tumors. Specifically, stage II might benefit from 5-fluorouracil-based adjuvant chemotherapy regimens. New data suggest possible advantages irinotecan-based regimens, these findings require further clarification. Characterization basis CRC underway initial results show mutations encoding kinases candidate with tracts over-represented Transcriptome expression profiles systems biology approaches providing opportunity develop targeted therapeutics for