The association of caveolae, actin, and the dystrophin-glycoprotein complex: a role in smooth muscle phenotype and function?

摘要: Smooth muscle cells exhibit phenotypic and mechanical plasticity. During maturation, signalling pathways controlling actin dynamics modulate contractile apparatus-associated gene transcription apparatus remodelling resulting from length change. Differentiated myocytes accumulate abundant caveolae that evolve the structural association of lipid rafts with caveolin-1, a protein domains confer unique functional properties. Caveolae caveolin-1 participate in receptor-mediated signalling, thus contribute to diversity phenotypically similar myocytes. In mature smooth muscle, are partitioned into discrete linear aligned proteins tether extracellular matrix. Caveolin-1 binds beta-dystroglycan, subunit dystrophin glycoprotein complex (DGC), filamin, an binding organizes cortical actin, which integrins focal adhesion complexes anchored. The DGC is linked cytoskeleton by receptor for laminin. Thus, caveolin-associated receptors via dynamic filamentous network. Despite development transgenic models investigate caveolins membrane-associated actin-linking skeletal cardiac function, only superficial understanding this phenotype function has emerged.