Activation of cortical somatostatin interneurons rescues synapse loss and motor deficits after acute MPTP infusion
作者： Kai Chen , Guang Yang , Kwok-Fai So , Li Zhang
DOI: 10.1016/J.ISCI.2019.06.040
关键词:
摘要: Summary Adult dendritic spines present structural and functional plasticity, which forms the basis of learning memory. To provide in vivo evidence spine plasticity under neurotoxicity, we generated an acute motor deficit model by single injection 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into adult mice. Acute MPTP infusion impairs learnings across test paradigms. In vivo two-photon imaging further revealed MPTP-induced prominent loss substantially increased calcium spikes in apical tufts layer 5 pyramidal neurons cortex. also decreased activity somatostatin (SST)-expressing inhibitory interneurons. Further chemogenetic re-activation SST interneurons reversed hyperactivation dendrites, rescued loss, enhanced learning. Taken together, our study reports deficits suggests potency modulating local transmission to relieve neurological disorders.
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