Structure and evolutionary origins of the CMG complex
作者： Silvia Onesti , Stuart A. MacNeill
DOI: 10.1007/S00412-013-0397-X
关键词:
摘要: The CMG (Cdc45–MCM–GINS) complex is the eukaryotic replicative helicase, enzyme that unwinds double-stranded DNA at replication forks. All three components of are essential for its function, but only in case MCM, molecular motor harnesses energy ATP hydrolysis to catalyse strand separation, function clear. Here, we review current knowledge three-dimensional structure and highlight recent advances our understanding evolutionary origins.
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