A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder.

摘要: Impaired executive inhibition is a core deficit of attention hyperactivity disorder (ADHD), which common childhood-onset psychiatric with high heritability. In this study, we performed two-stage genome-wide association study in ADHD Han Chinese. We used the Stroop color-word interference test to evaluate inhibition. After quality control, 780 samples phenotype and covariate data were included discovery stage, whereas 922 replication stage. identified one new significant locus at 7p22.3 for word time (rs11514810, P=3.42E-09 discovery, P=0.01176 combined P=5.249E-09). Regulatory feature analysis expression quantitative trait loci (eQTL) showed that contributes MICALL2 human brain. Most genes network interacting associated disorders. Furthermore, hyperactive-impulsive-like behavior was induced by reducing zebrafish gene homologous MICALL2, could be rescued tomoxetine (atomoxetine), clinical medication ADHD. Our results suggested susceptibility deficiency related hyperactive-impulsive ADHD, further emphasizing possible role neurodevelopmental pathogenic mechanism