作者: Seung-Min Lee , Jiyoung Moon , Ji Hyung Chung , Yong-Jun Cha , Min-Jeong Shin
DOI: 10.1016/J.FCT.2013.03.008
关键词:
摘要: The aim of this study was to examine whether oral supplementation quercetin-rich onion peel extract (OPE) influences blood coagulation and arterial thrombosis in Sprague-Dawley (SD) rats. 24 male rats, 5 weeks old, were divided into three groups with different diets (C: control, 2mg OPE: chow diet OPE supplementation, 10mg supplementation) for 6 weeks. Blood parameters including prothrombin time (PT), activated partial thromboplastin (aPTT) platelet aggregation examined. did not affect cholesterol levels but significantly decreased triglyceride glucose levels. PT, aPTT among all tested groups. However, vivo delayed that fed compared the control group. In addition, greatly diminished thrombin-induced expression tissue factor human umbilical vein endothelial cells (HUVECs), a initiator. extracellular signal-regulated kinase (ERK) c-Jun N-terminal (JNK) signaling pathways by thrombin treatment prevented pre-treatment. These results indicate may have anti-thrombotic effects through restricting induced via down-regulating mitogen-activated protein (MAPK) activation upon stimulus, leading prolongation thrombosis.