Diabetic nephropathy is associated with gene expression levels of oxidative phosphorylation and related pathways.

摘要: The in vitro behavior of skin fibroblasts from patients with or without diabetic nephropathy is associated risk. Here we compared fibroblast gene expression profiles two groups type 1 patients: 20 very fast (“fast-track”) versus slow (“slow-track”) rates development lesions. Gene grown 25 mmol/l glucose for 36 h were assessed by Affymetrix HG-U133A GeneChips to determine the proportion genes a given biological pathway that directionally consistent their group differences. Five pathways reached statistical significance. All had significantly greater proportions higher levels fast-track group. These pathways, first four which are closely related and have overlapping genes, included oxidative phosphorylation ( P = 0.017), citrate cycle 0.037), propanoate metabolism 0.044), transcription factors 0.046). results support concept upstream may be important pathogenesis nephropathy. Whether these findings reflect inherent genetic cellular characteristics, “cell memory,” both requires further study.