Arginine inhibits the malignant transformation induced by interferon-gamma through the NF-κB-GCN2/eIF2α signaling pathway in mammary epithelial cells in vitro and in vivo.

摘要: Abstract Breast cancer is the most common female malignant tumors in world. It seriously affects women's physical and mental health leading cause of death among women. Our previous study demonstrated that diet-derived IFN-γ promoted transformation primary bovine mammary epithelial cells by accelerating arginine depletion. The current aimed to explore whether addition could inhibit degree its molecular mechanism. results indicate alleviate induced IFN-γ, including reducing cell proliferation, migration colony formation, through NF-κB-GCN2/eIF2α pathway. vivo experiments also consistently confirmed supplementation significantly tumor growth tumor-bearing mice. Furthermore, investigation clinical data revealed plasma or tissue from human breast patients owned lower level higher than with benign disease, showing may be a potential control target. findings demonstrate supplement antagonize (nutritionally induced) both vitro vivo, was This might provide novel strategy for prevention treatment regarding nutrition.