Evaluation of the dynamic predictors of fluid responsiveness in dogs receiving goal-directed fluid therapy

摘要: Abstract Objectives Goal-directed fluid therapy (GDFT) based on pulse pressure variation (PPV) was used in anaesthetized dogs undergoing abdominal surgeries. The aims were 1) to evaluate the success rate of PPV ≥13% detecting responsiveness [delta stroke volume (ΔSV) ≥10%]; 2) assess correlation between PPV, systolic (SPV), Plethysmograph Variability Index (PVI) and central venous (CVP) 3) establish threshold value for PVI that would predict a indirectly discriminate responders from nonresponders therapy. Study design Clinical, prospective, interventional study. Animals A total 63 client-owned scheduled procedures. Methods SPV calculated manually invasive blood trace Datex monitor. recorded Masimo oximeter. Fluid challenge (10 mL kg−1 Compound Sodium Lactate) performed when and/or mean arterial (MAP) Results ≥ 13% reliably predicted 82.9% cases. There positive (r = 0.84%), logPVI (r = 0.46) as well 0.45). Noninvasive should (13%) with 97% sensitivity 68% specificity. no statistically significant CVP. Conclusions is useful clinical tool detect occult hypovolaemia cardiovascular response challenge. Use recommended part GDFT