Decreased central venous oxygen saturation despite normalization of heart rate and blood pressure post shock resuscitation in sick dogs.

作者: Brian C. Young , Jennifer E. Prittie , Philip Fox , Linda J. Barton

DOI: 10.1111/VEC.12154

关键词:

摘要: Objective To evaluate traditional and global perfusion parameters in clinical canine shock patients, to for occult hypoperfusion as evidenced by low central venous oxygen saturation or high plasma lactate concentrations patients resuscitated endpoints. Design Clinical observational trial designed with a 1-year data entry period patient follow-up of 28 days posthospital presentation. Setting Large, private urban teaching hospital, emergency critical care center. Animals Adult presenting the department untreated shock. Interventions None. Measurements Main Results Patients received fluid resuscitation normalize based on physical examination arterial blood pressure (BP). Monitoring (CVP) (ScvO2) was feasible current standard interventions critically ill, client-owned dogs. Decreased ScvO2 observed 37.8% normal parameters. Hyperlactatemia commonly recorded. Conclusions Decreased exists significant proportion ill dogs following shock, providing relevant target population implementation more standardized early goal-directed therapy bundle veterinary patients. Normalization heart rate, pressure, mentation, directed may be attained despite persistence tissue debt.

参考文章(53)
Paul C Hébert, George Wells, Morris A Blajchman, John Marshall, Claudio Martin, Giuseppe Pagliarello, Martin Tweeddale, Irwin Schweitzer, Elizabeth Yetisir, Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group, A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care The New England Journal of Medicine. ,vol. 340, pp. 409- 417 ,(1999) , 10.1056/NEJM199902113400601
Melissa L. Holahan, Andrew J. Brown, Kenneth J. Drobatz, The association of blood lactate concentration with outcome in dogs with idiopathic immune-mediated hemolytic anemia: 173 cases (2003-2006). Journal of Veterinary Emergency and Critical Care. ,vol. 20, pp. 413- 420 ,(2010) , 10.1111/J.1476-4431.2010.00551.X
Marco Ranucci, , Giuseppe Isgrò, Concetta Carlucci, Teresa De La Torre, Stefania Enginoli, Alessandro Frigiola, Central venous oxygen saturation and blood lactate levels during cardiopulmonary bypass are associated with outcome after pediatric cardiac surgery Critical Care. ,vol. 14, pp. 1- 10 ,(2010) , 10.1186/CC9217
Abele Donati, Silvia Loggi, Jean-Charles Preiser, Giovanni Orsetti, Cristopher Münch, Vincenzo Gabbanelli, Paolo Pelaia, Paolo Pietropaoli, Goal-Directed Intraoperative Therapy Reduces Morbidity and Length of Hospital Stay in High-Risk Surgical Patients Chest. ,vol. 132, pp. 1817- 1824 ,(2007) , 10.1378/CHEST.07-0621
J. DENIS EDWARDS, Oxygen transport in cardiogenic and septic shock. Critical Care Medicine. ,vol. 19, pp. 658- 663 ,(1991) , 10.1097/00003246-199105000-00012
Connie K. Stevenson,, Beverly A. Kidney,, Tanya Duke,, Elisabeth C. R. Snead,, Raul C. Mainar-Jaime,, Marion L. Jackson, Serial blood lactate concentrations in systemically ill dogs Veterinary Clinical Pathology. ,vol. 36, pp. 234- 239 ,(2007) , 10.1111/J.1939-165X.2007.TB00217.X
David Bihari, Mark Smithies, Alexander Gimson, Jack Tinker, The Effects of Vasodilation with Prostacyclin on Oxygen Delivery and Uptake in Critically Ill Patients New England Journal of Medicine. ,vol. 317, pp. 397- 403 ,(1987) , 10.1056/NEJM198708133170701
Pekka Pölönen, Esko Ruokonen, Mikko Hippeläinen, Mikko Pöyhönen, Jukka Takala, A prospective, randomized study of goal-oriented hemodynamic therapy in cardiac surgical patients. Anesthesia & Analgesia. ,vol. 90, pp. 1052- 1059 ,(2000) , 10.1097/00000539-200005000-00010
Mirinda Nel, Remo G. Lobetti, Ninette Keller, Peter N. Thompson, Prognostic value of blood lactate, blood glucose, and hematocrit in canine babesiosis Journal of Veterinary Internal Medicine. ,vol. 18, pp. 471- 476 ,(2004) , 10.1111/J.1939-1676.2004.TB02569.X