The association of blood lactate concentration with outcome in dogs with idiopathic immune-mediated hemolytic anemia: 173 cases (2003-2006).

摘要: Objective – To determine the association of blood lactate with outcome and response to transfusion therapy in dogs idiopathic immune-mediated hemolytic anemia (IMHA). Design Retrospective study. Setting Urban veterinary small animal emergency hospital. Animals One hundred seventy-three client-owned IMHA. Interventions None. Measurements Main Results Serial concentration, therapeutic interventions, were recorded. Nonsurvivors defined as those that died or euthanized. thirty-three (77%) survived, 35 (20%) euthanized, 5 (3%) died. forty-five (84%; 145/173) had a concentration above laboratory reference interval [0.46–2.31 mmol/L] on presentation. Blood at presentation was higher nonsurvivors (median 4.8 mmol/L; 0.5–13.6) compared survivors 2.9 mmol/L; 0.3–13.2) (P<0.01). All presenting hyperlactatemia normalized (<2.0 mmol/L) within 6 hours admission whereas, 71% persistent survived (P=0.034). Lactate positively correlated age, BUN, alkaline phosphatase, inversely PCV. Receiver operating curve analysis for test an area under 0.69 optimal cutoff 4.4 mmol/L correctly predicting 73% time (sensitivity 60%, specificity 77%). Conclusions significantly than survivors. previously reported variables but admission, predictor less optimal. However, serial measurements may be more predictive patients after likely survive. Prospective studies evaluating while controlling other provide further insight into measurement prognostic indicator animals IMHA.