Plasma osteopontin levels in multiple sclerosis.

摘要: Abstract Osteopontin (OPN) is a pleiotropic integrin binding protein with functions in cell-mediated immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN may play an important role the pathogenesis of experimental autoimmune encephalomyelitis multiple sclerosis (MS). Here, we investigated plasma levels 221 MS patients 36 healthy controls using enzyme-linked immunoassay. The group comprised 71 primary transitional progressive (PP/TP-MS), 35 secondary (SPMS), 115 relapsing–remitting (RRMS)[46 during clinical remission, 26 relapse, 43 treated interferon-beta (IFNβ)]. Levels were elevated SPMS compared controls, RRMS PP/TP-MS patients. Patients relapse presented higher than remission. When classified based on progression neurological disability, inverse relation between disability was observed only relapsing MS. In receiving therapy IFNβ, similar to These findings suggest involved both acute chronic disease activity, thus expanding suggested by previous studies. Furthermore, different profiles found relapses its apparent lack influence phenotypes raise interesting questions actual