Heat-shock protein 70 and heat-shock protein 90 associate with Toll-like receptor 4 in response to bacterial lipopolysaccharide

摘要: Mammalian responses to bacterial LPS (lipopolysaccharide) from the outer membrane of Gram-negative bacteria can lead an uncontrolled inflammatory response that be deadly for host. It has been shown innate immune system employs at least three cell surface receptors, CD14, TLR4 (Toll-like receptor 4) and MD-2, in order recognize LPS. In our previous work we have found Hsps (heat-shock proteins) are also involved recognition products. Their presence on surface, as well their involvement process, poorly understood. present study investigated association with Hsp70 Hsp90 following stimulation, both intracellularly. Our results show form a cluster within lipid microdomains stimulation. addition, seem TLR4/LPS trafficking targeting Golgi apparatus, since upon stimulation targeted along TLR4. The sheds new light into response.