Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
作者： Theresa Lopez , Douglas Hanahan
DOI: 10.1016/S1535-6108(02)00055-7
关键词:
摘要: In a prototypical model of multistage tumorigenesis involving pancreatic islets in RIP1-Tag2 transgenic mice, activation insulin-like growth factor II (IGF-II) was previously shown to serve as survival that inhibited apoptosis. Now IGF-1R, the receptor tyrosine kinase for IGF-II, has been found be variably upregulated, first uniformly dysplastic and angiogenic progenitors then focally at margins invasive regions carcinomas. When levels IGF-1R were forcibly elevated throughout islet tumorigenesis, progression accelerated all stages pathway, although apoptosis not differentially suppressed. Notably, encapsulated tumors absent; instead, carcinomas with downregulated E-cadherin prevalent, majority mice had local lymph node metastasis.
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sci-hub.se 参考文章(63)
E.A. Harrington, M.R. Bennett, A. Fanidi, G.I. Evan, c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. The EMBO Journal. ,vol. 13, pp. 3286- 3295 ,(1994) , 10.1002/J.1460-2075.1994.TB06630.X
E Chastre, Noe, C Gespach, Erik Bruyneel, Marcus Mareel, Extracellular regulation of cancer invasion: the E-cadherin-catenin and other pathways. CELL BEHAVIOUR: CONTROL AND MECHANISM OF MOTILITY. ,vol. 65, pp. 43- 62 ,(1999)
Lisa M. Coussens, Gabriele Bergers, Douglas Hanahan, Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis. The International Journal of Developmental Biology. ,vol. 42, pp. 995- 1002 ,(1998) , 10.1387/IJDB.9853830
Anne-Karina Perl, Ulf Dahl, Petra Wilgenbus, Harold Cremer, Henrik Semb, Gerhard Christofori, Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Nature Medicine. ,vol. 5, pp. 286- 291 ,(1999) , 10.1038/6502
Anne-Karina Perl, Petra Wilgenbus, Ulf Dahl, Henrik Semb, Gerhard Christofori, A causal role for E-cadherin in the transition from adenoma to carcinoma Nature. ,vol. 392, pp. 190- 193 ,(1998) , 10.1038/32433
Haim Werner, Derek LeRoith, The Role of the Insulin-like Growth Factor System in Human Cancer Advances in Cancer Research. ,vol. 68, pp. 183- 223 ,(1996) , 10.1016/S0065-230X(08)60354-1
Gabriele Bergers, Rolf Brekken, Gerald McMahon, Thiennu H. Vu, Takeshi Itoh, Kazuhiko Tamaki, Kazuhiko Tanzawa, Philip Thorpe, Shigeyoshi Itohara, Zena Werb, Douglas Hanahan, Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis Nature Cell Biology. ,vol. 2, pp. 737- 744 ,(2000) , 10.1038/35036374
David M. Cykert, Sandra E. Dunn, Jennifer S. Oh, J. Carl Barrett, Johann V. Torres, Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase kinase. Cancer Research. ,vol. 61, pp. 1367- 1374 ,(2001)
John W. Ludlow, Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRB and p53. The FASEB Journal. ,vol. 7, pp. 866- 871 ,(1993) , 10.1096/FASEBJ.7.10.8344486
Pnina Brodt, Roya Navab, Li Long, Regulation of the Mr 72,000 Type IV Collagenase by the Type I Insulin-like Growth Factor Receptor Cancer Research. ,vol. 58, pp. 3243- 3247 ,(1998)