Clonal chromosome abnormalities in tumor cells from patients with sporadic renal cell carcinomas.
作者： Svenja Frisch , Gyula Kovacs
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摘要: The karyotype of 75 sporadic, nonpapillary renal cell carcinomas was analyzed using chromosome banding techniques. Sixty-five tumors had near-diploid stemlines, and ten near-triploid or near-tetraploid stemlines. Aberration 3 detected in 71 cases. nonrandom changes on were monosomy 3, terminal deletions, unbalanced translocations; the 3p13-pter segment identified as minimal common deletion. rearrangement 3p only change 13 tumors. Abnormalities 5 resulting trisomy for 5q22-qter region found 36 cases, while loss 14q22-qter observed 34 Trisomy 7 17 8 9 occurred 14 times each. Our data show that more than one specific chromosomal site may be involved development human carcinomas.
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