Recruitment of myeloid and plasmacytoid dendritic cells in cervical mucosa during Chlamydia trachomatis infection

摘要: The mobilization of myeloid dendritic cells (mDCs) and plasmacytoid (pDCs) to the cervix during chlamydial infection is not fully understood, role these in immunopathogenesis largely unknown. As an effective vaccine control currently unavailable, understanding regulation local immune response becomes a necessity. Therefore, mDC pDC populations were analysed peripheral blood cervical samples controls Chlamydia-positive women, with or without mucopurulent cervicitis (MPC). Cervical cytokines C-reactive protein levels serum quantified by ELISA infectious load culture. Chlamydia trachomatis mobilized both mDCs pDCs mucosa. recruited more often women MPC (p <0.05) they correlated significantly load, interleukin-8 (IL-8) levels. Upregulation surface expression co-stimulatory molecules (CD80, CD83 CD86) on was observed but significant only for mDCs. Significantly higher IL-1 beta, IL-6 IL-8 MPC; however, after therapy, decreased significantly. Median numbers therapy infected as compared pDCs, which found be lower therapy. These results thus suggest that infection, are cervix, their number possible immunological functions may differ pathological condition. associated inflammatory factors, suggesting possibly involved infections due Chlamydia.