Effects of dietary fish oil on renal insufficiency in rats with subtotal nephrectomy.

摘要: Effects of dietary fish oil on renal insufficiency in rats with subtotal nephrectomy. We studied the effects progression Five weeks after a 1-2/3 nephrectomy, sixteen were fed two different diets which differed only fat composition. Lipid control diet was primarily beef tallow; that experimental diet, menhaden oil. Fish oil–fed had significant increases plasma creatinines, decreases urinary PGE 2 and accelerated death rates. An additional twelve underwent 1-1/3 nephrectomies, same manipulations, followed by clearance, histologic biochemical studies 12 diets. again did worse, decreased glomerular filtration rates fractions, more proteinuria sclerosis. Glomeruli slices cortex, medulla papillae from produced much less TXB than controls. oil–induced suppression may be deleterious this model outweigh beneficial effect derived TXA suppression. In contrast to oil's potentially therapeutic role cardiovascular immune–mediated disease, is detrimental rat renoprival nephropathy. This illustrates importance examining fatty acid manipulation individually for each disease entity.