Mechanisms of Prednisolone Action in Erythropoiesis

摘要: Daily administration for 4 days of doses methyl prednisolone acetate (MPA) ranging from 0.5 to 4.0 mg depressed erythropoiesis in normal mice; this effect was partially overcome by erythropoiesisstimulating factor (ESF). The mechanism inhibitory action MPA on involves: 1) a diminution the numbers and/or response hemic stem cells ESF as seen both and plethoric mice, 2) depression production, noted with higher dose level (4 mg) mice subjected hypoxia. ability counteract erythropoiesis-stimulating hypoxia not attributable presence erythropoiesisinhibiting factors plasma. This shown inability plasma secured MPAtreated depress or inhibit exogenous mice. (Endocrinology 81: 363, 1967)