Renal cyclic GMP and cholinergic mechanisms in erythropoietin production.
作者： George M. Rodgers , James W. Fisher , William J. George
DOI: 10.1016/0024-3205(75)90463-4
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摘要: Abstract Cobalt treatment in rats produced sequential elevations both renal cyclic GMP concentration and lysosomal enzyme activity plasma. These effects of cobalt were significantly inhibited by atropine pretreatment, as was cobalt-mediated erythropoietin (ESF) production. Physostigmine, an inhibitor acetylcholinesterase, potentiated the erythropoietic effect cobalt. data are consistent with hypothesis that is associated a cholinergic mechanism involving GMP-mediated release. events may precede previously described AMP activation factor.
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