Normal-phase dynamic (solvent-generated) molecular complexation chromatography using anionic ion exchangers
作者： G. Szepesi , M. Gazdag , R. Iváncsics
DOI: 10.1016/S0021-9673(00)80120-X
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摘要: Abstract A chiral ion exchanger, (+)- and (−)-antipodes of 10-camphorsulphonic acid, was applied for the normal-phase solvent-generated molecular complexation chromatography optical isomers alkaloids. It dissolved in less polar phase a three-component eluent mixture consisting solvents having different polarities. Separations were performed on bonded stationary (cyanopropylsilica). Remarkably high relative retentions archieved, permitting rapid separation eburnane alkaloids selected as models investigations. The influence mobile composition antipode selection exchanger selectivity efficiency is discussed. Some applications proposed method, including eight vincamine, are
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sci-hub.se 参考文章(29)
John H. Knox, George R. Laird, Soap chromatography—a new high-performance liquid chromatographic technique for separation of ionizable materials Journal of Chromatography A. ,vol. 122, pp. 17- 34 ,(1976) , 10.1016/S0021-9673(00)82234-7
G. Szepesi, M. Gazdag, R. Iváncsics, Normal-phase dynamic (solvent-generated) molecular complexation chromatography using anionic ion exchangers Journal of Chromatography A. ,vol. 241, pp. 153- 167 ,(1982) , 10.1016/S0021-9673(00)82400-0
G. Szepesi, M. Gazdag, High-performance liquid chromatography of eburnane alkaloids Journal of Chromatography A. ,vol. 204, pp. 341- 348 ,(1981) , 10.1016/S0021-9673(00)81677-5
V.A. Davankov, A.S. Bochkov, Yu.P. Belov, Ligand-exchange chromatography of racemates : XV. Resolution of α-amino acids on reversed-phase silica gels coated with n-decyl-l-histidine☆ Journal of Chromatography A. ,vol. 218, pp. 547- 557 ,(1981) , 10.1016/S0021-9673(00)82079-8
G. Szepesi, M. Gazdag, High-performance liquid chromatography of eburnane alkaloids : II. Separations on silica Journal of Chromatography A. ,vol. 205, pp. 57- 64 ,(1981) , 10.1016/S0021-9673(00)81813-0
A.A. Kurganov, V.A. Davankov, Ligand-exchange chromatography of racemates : XVI. Microbore column chromatography of amino acid racemates using N,N,N′,N∼-tetramethyl-(R)-propanediamine-1,2-copper(II) complexes as chiral additives to the eluent Journal of Chromatography A. ,vol. 218, pp. 559- 567 ,(1981) , 10.1016/S0021-9673(00)82080-4
G. Szepesi, M. Gazdag, L. Terdy, Separation of ergotoxine alkaloids by high-performance liquid chromatography on silica Journal of Chromatography A. ,vol. 191, pp. 101- 108 ,(1980) , 10.1016/S0021-9673(00)86368-2
James N. LePage, Wolfgang. Lindner, Geoffrey. Davies, David E. Seitz, Barry L. Karger, Resolution of the optical isomers of dansyl amino acids by reversed phase liquid chromatography with optically active metal chelate additives Analytical Chemistry. ,vol. 51, pp. 433- 435 ,(1979) , 10.1021/AC50039A026
D. P. Wittmer, N. O. Nuessle, W. G. Haney, Simultaneous analysis of tartrazine and its intermediates by reversed phase liquid chromatography. Analytical Chemistry. ,vol. 47, pp. 1422- 1423 ,(1975) , 10.1021/AC60358A072
Curt Pettersson, Göran Schill, Separation of enantiomeric amines by ion-pair chromatography Journal of Chromatography A. ,vol. 204, pp. 179- 183 ,(1981) , 10.1016/S0021-9673(00)81656-8