Homozygous Deletions of the p16 Tumor-Suppressor Gene Are Associated With Lymphoid Transformation of Chronic Myeloid Leukemia
作者： H Sill , JM Goldman , NC Cross
DOI: 10.1182/BLOOD.V85.8.2013.BLOODJOURNAL8582013
关键词:
摘要: The p16 gene, also referred to as MTS1, INK4, CDK4I, or CDKN2, at chromosome 9p21 has recently been described a tumor suppressor that may be involved in wide range of tumors. We have used semiquantitative multiplex polymerase chain reaction assay search for deletions the gene 34 patients with chronic myeloid leukemia blast crisis (CML BC), 19 acute lymphoblastic (ALL), and 25 (AML). Homozygous exons were found 5 10 (50%) CML lymphoid BC (26%) ALL patients, but only 1 (2%) case AML. No nonlymphoid phenotype. Comparison phase DNA remission individuals showed acquired not inherited, directly implicating these lesions pathogenesis disease. conclude functional elimination closely mapping is significant number transformation.
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bloodjournal.org参考文章(16)
J Hebert, JM Cayuela, J Berkeley, F Sigaux, Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias. Blood. ,vol. 84, pp. 4038- 4044 ,(1994) , 10.1182/BLOOD.V84.12.4038.BLOODJOURNAL84124038
S Ogawa, N Hirano, N Sato, T Takahashi, A Hangaishi, K Tanaka, M Kurokawa, T Tanaka, K Mitani, Y Yazaki, Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias Blood. ,vol. 84, pp. 2431- 2435 ,(1994) , 10.1182/BLOOD.V84.8.2431.2431
Deirdre K. LORD, Nicholas C. P. CROSS, Maria A. BEVILACQUA, Susan H. RIDER, Patricia A. GORMAN, Ann V. GROVES, Donald W. MOSS, Denise SHEER, Timothy M. COX, Type 5 acid phosphatase. Sequence, expression and chromosomal localization of a differentiation-associated protein of the human macrophage. FEBS Journal. ,vol. 189, pp. 287- 293 ,(1990) , 10.1111/J.1432-1033.1990.TB15488.X
Christopher J. Hussussian, Jeffery P. Struewing, Alisa M. Goldstein, Paul A. T. Higgins, Delphine S. Ally, Michelle D. Sheahan, Wallace H. Clark, Margaret A. Tucker, Nicholas C. Dracopoli, Germline p16 mutations in familial melanoma. Nature Genetics. ,vol. 8, pp. 15- 21 ,(1994) , 10.1038/NG0994-15
R. Day, B. Johnson, M. Skolnick, A Kamb, N. Gruis, J Weaver-Feldhaus, Q Liu, K Harshman, S. Tavtigian, E Stockert, A cell cycle regulator potentially involved in genesis of many tumor types Science. ,vol. 264, pp. 436- 440 ,(1994) , 10.1126/SCIENCE.8153634
Tsutomu Nobori, Kaoru Miura, David J. Wu, Augusto Lois, Kenji Takabayashi, Dennis A. Carson, Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers Nature. ,vol. 368, pp. 753- 756 ,(1994) , 10.1038/368753A0
Bert Vogelstein, Kenneth W. Kinzler, The multistep nature of cancer. Trends in Genetics. ,vol. 9, pp. 138- 141 ,(1993) , 10.1016/0168-9525(93)90209-Z
B.C. Sykes, DNA IN HERITABLE DISEASE The Lancet. ,vol. 322, pp. 787- 788 ,(1983) , 10.1016/S0140-6736(83)92314-0
Mihael H. Polymeropoulos, Hong Xiao, Denise S. Rath, Carl R. Merril, Tetranucleotide repeat polymorphism at the human tyrosine hydroxylase gene (TH) Nucleic Acids Research. ,vol. 19, pp. 3753- 3753 ,(1991) , 10.1093/NAR/19.13.3753
Andreas Neubauer, Beatrix Neubauer, Edison Liu, Polymerase chain reaction based assay to detect allelic loss in human DNA: loss of β-interleron gene in chronic myelogeneous leukemia Nucleic Acids Research. ,vol. 18, pp. 993- 998 ,(1990) , 10.1093/NAR/18.4.993