What is the function of neuronal AP-3?

摘要: Neurotransmission requires the proper organization and rapid recycling of synaptic vesicles. Rapid retrieval has been suggested to occur either by kiss-and-stay or kiss-and-run mechanisms, whereas classical is mediated clathrin-dependent endocytosis. Molecular coats are key components in selection cargos, AP-2 (adaptor protein 2) playing a prominent role vesicle Another coat protein, AP-3, implicated biogenesis generation secretory lysosomal-related organelles. In present review, we will particularly focus on recent data concerning vesicles function AP-3 v-SNARE (vesicular soluble N-ethylmaleimide-sensitive fusion protein-attachment receptor) TI-VAMP (tetanus neurotoxin-insensitive vesicle-associated membrane protein) these processes. We propose that plays an important regulatory neurons which contributes basal stimulated exocytosis