A Valuation of Infusion Therapy to Preserve Islet Function in Type 1 Diabetes

摘要: Abstract Objectives Recent advances in monoclonal antibody therapies offer the prospect of prevention or amelioration type 1 diabetes mellitus (T1DM). The present study was designed to capture UK (English and Scottish) preference weights for process undergoing infusion therapy likely outcomes treatment children (8–12 years), adolescents (13–17 adults. Methods Vignette descriptions T1DM health states (describing reduced insulin need) were constructed based on qualitative interviews with people diabetes, clinicians findings from a literature review. Utilities elicited each state using standard gamble interview general public, adults parents diabetes. Participants also completed other outcome measures—EQ-5D, Pediatric Quality-of-Life Inventory, Hyperglycemic Fear Survey. Mixed model analyseswere used estimate influence utility different participant characteristics. Results Self-report questionnaires indicated nature degree impact adults', adolescents', children's quality life, reporting lowest health-related quality-of-life profile all groups. mixed analysis that significant predictor participants gave significantly higher utilities compared public ( P = 0.02). Conclusion (or diabetes) place value reducing need injections; also, recognize disutility cycles. These values are suitable supporting estimates cost-effectiveness T1DM.