Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents

摘要: Efforts to discover new cancer drugs and predict their clinical activity are limited by the fact that laboratory models test drug efficacy do not faithfully recapitulate this complex disease. One important model system for evaluating candidate anticancer agents is human tumour-derived cell lines. Although cultured cells can exhibit distinct properties compared with naturally growing counterparts, recent technologies facilitate parallel analysis of large panels such lines, together genomic define genetic constitution, have revitalized efforts use lines assess utility investigational predictive biomarkers.