GATA3 immunohistochemistry in urothelial carcinoma of the upper urinary tract as a urothelial marker and a prognosticator

摘要: Immunohistochemistry of a transcription factor, GATA3, has been widely used as promising urothelial marker in diagnostic surgical pathology practice. However, the expression status GATA3 upper urinary tract carcinomas (UUTUCs) and its prognostic significance have not fully investigated. We immunohistochemically stained for 99 UUTUC samples paired nonneoplastic tissues. was positive 51 (51.5%; 32 [32.3%] weak, 11 [11.1%] moderate, 8 [8.1%] strong) UUTUCs, which significantly lower than benign urothelium (79 [96.3%] 82; 33 [40.2%] 35 [42.7%] [13.4%] strong; P<.001). there were no statistically significant associations between tumor grade, pT stage, lymph node involvement, or distant metastasis. Meanwhile, rate positivity higher (P=.004) ureteral tumors (66.0%) renal pelvic (35.6%). Kaplan-Meier log-rank tests revealed that negativity associated with recurrence-free survival (P=.037 all cases, P=.026 muscle-invasive tumors) cancer-specific (P=.007 P=.012 tumors, P=.035 cases adjuvant chemotherapy) rates. Multivariate analysis further identified strong correlations progression (all cases: hazard ratio [HR], 0.479 [95% confidence interval {CI},0.229-1.003; P=.051]; tumors: HR, 0.387 CI, 0.166-0.903; P=.028) mortality 0.354 0.135-0.925; P=.034]; 0.402 0.149-1.086; P=.072]). Thus, compared urothelium, decrease seen. Moreover, loss found to be an independent predictor poor patient outcomes. Of note only roughly half high-grade and/or UUTUCs immunoreactive GATA3.