Determination of compatibility of a set of chemical modifications with an amino-acid chain
作者： Heinz Breu , Sean Keating
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摘要: Peptide mass mapping is a technique whereby masses determined from spectrometry of protein digest are compared to the theoretical peptides derived reference protein, specified as an amino-acid sequence. In some cases differences between experimental and can be accounted for by chemical modifications actual with respect reference, often result post-translational modification (PTM). Typically such applicable specific sets residues. Analysis these therefore lead identification PTMs. various cases, it desirable that analysis in general allow possibility peptide having several different PTMs, furthermore compatibility putative combination PTMs sequence verified. Embodiments described herein wherein verification formulated problem graph theory. Theory implementation solution discussed described.
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