Negative correlation between the ratio of Bax to Bcl-2 and the size of tumor treated by culture supernatants from Kupffer cells.
作者： George G Chen , Paul BS Lai , Xu Hu , Isa KY Lam , Ernest CW Chak
关键词:
摘要: Kupffer cells play an important role in keeping liver from occurrence of tumors. Apoptosis is thought to be a major mechanism responsible for the anti-tumor function cells. Previous studies have mainly concentrated on direct contact and interaction between tumor The present experiment investigate apoptotic pathway induced by culture supernatant activated levels Bax, Bcl-2 iNOS were analyzed vivo mouse model, which was treated with results showed that expression Bax significantly increased while decreased when supernatants alteration resulted increase ratio Bcl-2, had negative correlation size positive iNOS. TNFα apoptosis also cells, compared those received no treatment. In conclusion, able change balance favor former. useful index evaluate Our suggests may result TNFα.
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